could someone explain how the research here might help with metastatic disease?

I can't answer your question precisely, but I can say that a better understanding of proteins (how to predict their shapes and functions from amino acid sequences, how to design new ones, etc) will help medical science move forward in pretty much all areas.

So while I'm not sure if R@H is working on something specific right now, I'm pretty sure that any breakthroughs it makes will help indirectly.

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I can't answer your question precisely, but I can say that a better understanding of proteins (how to predict their shapes and functions from amino acid sequences, how to design new ones, etc) will help medical science move forward in pretty much all areas.

So while I'm not sure if R@H is working on something specific right now, I'm pretty sure that any breakthroughs it makes will help indirectly.

Another project is working on modelling cell adhesion for research on metastatic disease, initially cancer:

http://cels-at-home-dev.dyndns.org/cels/

It doesn't generate workunits fast enough to keep most of the participating computers busy, so you're not likely to want to make it your only BOINC project on any machine. It's recently out of beta test.

I haven't noticed anything there on how much help they get from R@H.